Abstract

Objective: The main goal of this retrospective observational clinical study was to investigate the risk factors for fracture in individuals with proximal femoral fibrous dysplasia (FD). Methods: In individuals with FD of the proximal femur according to whether or not they had experienced a hip fracture, we looked at body mass index, bilateral radiographs on both sides, femoral neck shaft angle measures, and markers of bone metabolism. Age, sex, clinical classification, anatomic classification, femoral neck shaft angle, pro-collagen type I N-terminal pro-peptide, type I collagen C-terminal telopeptide, and osteocalcin levels were the nine clinical variables used for univariate analysis. Multivariate logistic analysis was then applied to factors that showed out in the univariate study. Results: In univariate analysis, the clinical classification, anatomic classification, femoral neck shaft angle, and osteocalcin level were found to be statistically significant risk variables for fracture. Multivariate analysis revealed that the osteocalcin level, femoral neck shaft angle, and anatomic classification were still important risk variables. Conclusion: In patients with FD of the proximal femur, the osteocalcin level, the femoral neck shaft angle, and other key risk variables for fracture could be used to direct the execution of a fracture prevention strategy.